The Stratton Lab is focused on understanding the molecular components that allow you to form, maintain and recall a memory. CaMKII (calcium-calmodulin dependent protein kinase II) is the center of our focus. This dodecameric kinase complex has several fascinating biochemical and biophysical properties and is known to play a hallmark role in long-term memory. We have recently shown, for the first time, that CaMKII can exchange subunits between complexes, but only as a result of activation. Subunit exchange may play a role in extending the lifetime of active CaMKII, which could be necessary for memory potentiation.
Our focus on CaMKII is centered on three major areas: frequency activation, subunit exchange, and downstream effectors. We strive to understand the protein regulation that drives synapse formation and maintenance at the molecular level. To uncover the complexity that exists in our neural networks, we explore the signaling properties and regulation of the proteins involved in memory formation. We aim to bridge the gap between information obtained at the animal level (e.g., transgenic mice) and information obtained at the molecular level (e.g., protein structure and regulation).
Hear from our current PhD candidates on their current projects below!
Take a look at our publications page for more information as well as some other helpful links!
Page updated
Google Sites
Report abuse